Paul Van Der Horst

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biotechnology research growth factor therapy fibrosis treatment alk5 inhibitor tgf beta signaling hepatocyte growth factor fgf modulation regenerative medicine clinical pipeline cells regeneration oral small molecule inhaled treatment idiopathic pulmonary fibrosis crohn's disease therapy disease-modifying treatment preclinical studies biotech innovation clinical trials fibrotic diseases organ function restoration small molecule drugs monoclonal antibodies expanding pipeline biotherapeutics fibrosis resolution organ-restricted therapy immunotherapy development gastrointestinal diseases phase 1 clinical trial phase 2 clinical trial systemic exposure prevention local concentration targeting innovative r&d advanced drug development tissue repair molecular pathways modulation fda orphan drug designation series financing venture capital support biotech partnerships scientific collaboration met receptor agonism indication expansion progressive organ failure treatment equity financing research & development biomarker identification clinical efficacy safety profile patient improvement strategies research expertise health care health wellness & fitness hospital & health care