Glen Ko

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mechanistic quantitative systems pharmacology modeling midd fih dosing ind support physiologicallybased pharmacokinetic models gene therapy models immunooncology models protein degrader models lysosomal disorder models hematological toxicity models diseaseprogression models antibodydrug conjugates models biotechnology research quantitative systems pharmacology qsp modeling drug development regulatory approvals first-in-human dosing fih projections physiologically-based pharmacokinetic models pbpk modeling gene therapy immuno-oncology antibody-drug conjugates protein degradation modeling hematological toxicity disease progression modeling model-informed drug development toxicology projections clinical trials support pharmacokinetics biopharmaceuticals fda approvals monoclonal antibodies small molecule therapy clinical dose prediction preclinical modeling biological modeling drug efficacy pharmacodynamics model validation treatment adherence modeling hepatitis c virus studies viral dynamics lysosomal disorders huntington's disease modeling gaucher disease modeling rare disease pharmacology accommodating population heterogeneity drug synthesis pharmacology preclinical to clinical translation dose-response relationship adverse event prediction combination therapies mechanistic insights clinical applications therapeutic modeling