Richard Jones

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pharmaceutical manufacturing biopharmaceutical sepsis septic shock clinical-stage precision medicine monoclonal antibody adrenomedullin vascular integrity enibarcimab fda fast track designation biomarker-guided therapy organ dysfunction mortality reduction dpp3 vascular leakage hemodynamic stability treatment efficacy phase ii trial biomarker identification critical illness adrenaline antibodies circulating dipeptidyl peptidase 3 immunotherapy acute care vascular endothelium life-threatening conditions patient heterogeneity clinical development scientific publications regulator of vascular integrity elevated levels acute heart failure tissue edema biomarker confirmation multicenter trial patient population double-blind trial randomized trial treatment effect improved outcomes hospital mortality sepsis crisis risk assessment preventive strategies knowledge translation pharmaceutical innovation pharmaceuticals medical