Michael Hennig

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structure based drug discovery membrane proteins serial crystallography cryoelectron microscopy free electron laser synchrotron biostructure biotechnology research drug discovery structure-based drug design cryo-em x-ray crystallography gpcrs ion channels transporters enzymes biophysical analysis ligand design ligand characterization protein purification construct engineering hit finding preclinical compounds high-throughput screening biotechnology pharmaceutical partners academic partnerships proprietary compounds drug development molecular modeling computational chemistry fragment-based drug discovery nanobodies pro-macrobodies binding kinetics ligand binding allosteric modulation thermal stability viral protein research structural biology innovations protein crystallization virtual screening pharmacophore modeling ultra-large libraries precision medicine biophysics in drug discovery molecular dynamics simulations therapeutic targets contract research organization target validation custom research services integrated lead discovery high-resolution structures membrane protein challenges clinical candidate optimization ai-assisted drug discovery drug lead acceleration