Stephane Boissel

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ocular diseases inherited retinal diseases irds gene therapy genomic medicines retinitis pigmentosa rp therapeutic innovation gene agnostic mutations photoreceptors cone viability factor anti-oxidative stress subretinal injection clinical-stage clinical trial mutation independent neuroprotective therapy aav-based delivery crispr/cas9 genome editing ocular drug discovery vision saving treatments progressive vision loss optical restoration blindness prevention patient outcomes dormant cones visual acuity restoration genetic mutation phototransduction cascade gene therapy approaches gene replacement genetic disorders advanced stage treatment biopharmaceutical pipeline treatment development safety data trials preliminary efficacy patient care optogenetics biological research genetic intervention therapeutic synergy long-term results active clinical research medical advancements therapy options retinal degeneration therapies combined therapy constructs