David Earp

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biotechnology research macrocycles cancer therapies drug discovery mxmo platform oral bioavailability protein-protein interaction clinically relevant cyclin inhibitors therapeutic targets biotherapeutics selectivity cell permeability synthetic lethality preclinical trials advanced cancer treatment biomedical innovation pharmaceutical development drug design ai & ml in drug discovery phase 1 clinical trials e2f pathway cdks preclinical studies biochemical assays macrocyclic peptides antineoplastic agents targeted therapy innovative treatments cell cycle regulation therapeutic efficacy pharmacokinetics drug-like properties compounds screening novel drug candidates cancer biology biotechnology patient populations drug metabolism mechanism of action chemical libraries molecular design chemical engineering biomarker discovery pharmaceutical sciences contract negotiation research collaboration science of macrocycles drug manufacturing