Paul Higham

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biotechnology research gpr65 immune cell receptor tumor microenvironment immunotherapy cancer treatment first-in-class small molecule inhibitor acid-sensing gpcr ptt-4256 immunosuppressive phenotype solid tumors clinical trials phase 1/2 study targeted therapy biotech drug discovery immuno-oncology cancer immunotherapy macrophage conditioning cytokine signaling t-cell activation tumor-associated macrophages immune evasion pathway anti-cancer drugs human genetic validation tumor microenvironment modulation gpr65 inhibitor oral bioavailability single-agent efficacy pharmacokinetics anti-tumorigenic pathways acidic ph phase 1 clinical study tumor types cancer patients treatment response biotech industry molecular targeting therapeutic strategy clinical development drug candidates biopharma cancer research scientific validation novel therapeutics biotechnology ecosystem collaborative partnerships patient outcomes therapeutic potential clinical advancement health care health wellness & fitness hospital & health care