James Kronauge

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in vitro biology adme systems nanotechnology organonachip organsonchips human-on-a-chip organ-on-a-chip drug discovery preclinical testing disease modeling multi-organ systems toxicology screening pharmacokinetics pharmacodynamics therapeutic development patient-derived models custom organ models ipsc technology drug interactions metabolite analysis toxicity prediction serum-free culture cell viability assays electrophysiology neuromuscular junction animal alternative microfluidic systems drug efficacy testing toxicity assessment biomarkers identification clinical trials organic platforms in vitro studies functional tissues translational medicine safety testing patient-specific models gene expression direct drug effects long-term culture real-time monitoring pharmaceutical research chemical testing individualized medicine therapeutic index gastrointestinal absorption blood-brain barrier models human response barrier tissues metabolic profiling systematic drug testing pharmaceutical innovation systems biology health care health wellness & fitness hospital & health care